Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity

Macrophages are phagocytes that play important roles in health and diseases. Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) converts cellular cholesterol to cholesteryl esters and is expressed in many cell types. Unlike global Acat1 knockout (KO), myeloid-specific Acat1 KO (Acat1(−)) does not cause...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Huang, Li-Hao, Melton, Elaina M., Li, Haibo, Sohn, Paul, Jung, DaeYoung, Tsai, Ching-Yi, Ma, Tian, Sano, Hiroyuki, Ha, HyeKyung, Friedline, Randall H., Kim, Jason K., Usherwood, Edward, Chang, Catherine C. Y., Chang, Ta-Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171008/
https://ncbi.nlm.nih.gov/pubmed/29533741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00174.2017
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