Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450(BM3) Variant

Cytochrome P450(BM3) catalyzes the hydroxylation and/or epoxidation of fatty acids, fatty amides, and alcohols. Protein engineering has produced P450(BM3) variants capable of accepting drug molecules normally metabolized by human P450 enzymes. The enhanced substrate promiscuity has been attributed t...

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Publicat a:Biophys J
Autors principals: Geronimo, Inacrist, Denning, Catherine A., Heidary, David K., Glazer, Edith C., Payne, Christina M.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
Matèries:
Proteins
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170655/
https://ncbi.nlm.nih.gov/pubmed/30224054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.026
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