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Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450(BM3) Variant
Cytochrome P450(BM3) catalyzes the hydroxylation and/or epoxidation of fatty acids, fatty amides, and alcohols. Protein engineering has produced P450(BM3) variants capable of accepting drug molecules normally metabolized by human P450 enzymes. The enhanced substrate promiscuity has been attributed t...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6170655/ https://ncbi.nlm.nih.gov/pubmed/30224054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.026 |
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