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MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences

Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well as their structure and function in acute myeloid leukemia (AML) remain mysterious. We combined a range of high-resolut...

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Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: L′Abbate, Alberto, Tolomeo, Doron, Cifola, Ingrid, Severgnini, Marco, Turchiano, Antonella, Augello, Bartolomeo, Squeo, Gabriella, D′Addabbo, Pietro, Traversa, Debora, Daniele, Giulia, Lonoce, Angelo, Pafundi, Mariella, Carella, Massimo, Palumbo, Orazio, Dolnik, Anna, Muehlematter, Dominique, Schoumans, Jacqueline, Van Roy, Nadine, De Bellis, Gianluca, Martinelli, Giovanni, Merla, Giuseppe, Bullinger, Lars, Haferlach, Claudia, Storlazzi, Clelia Tiziana
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170393/
https://ncbi.nlm.nih.gov/pubmed/29467491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0033-0
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