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t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders

Through a combined approach integrating RNA-Seq, SNP-array, FISH and PCR techniques, we identified two novel t(15;21) translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12. One is a complex t(15;21)(q24;q22), with both breakpoints mapped at the nucleotide level, joinin...

詳細記述

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書誌詳細
出版年:Mol Cancer
主要な著者: L’Abbate, Alberto, Tolomeo, Doron, De Astis, Francesca, Lonoce, Angelo, Cunsolo, Crocifissa Lo, Mühlematter, Dominique, Schoumans, Jacqueline, Vandenberghe, Peter, Van Hoof, Achilles, Palumbo, Orazio, Carella, Massimo, Mazza, Tommaso, Storlazzi, Clelia Tiziana
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681058/
https://ncbi.nlm.nih.gov/pubmed/26671595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0484-0
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