The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer

Genome amplification in the form of rings or giant rod-shaped marker chromosomes (RGMs) is a common genetic alteration in soft tissue tumors. The mitotic stability of these structures is often rescued by perfectly functioning analphoid neocentromeres, which therefore significantly contribute to canc...

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Bibliographic Details
Published in:Genetics
Main Authors: Macchia, Gemma, Severgnini, Marco, Purgato, Stefania, Tolomeo, Doron, Casciaro, Hilen, Cifola, Ingrid, L’Abbate, Alberto, Loverro, Anna, Palumbo, Orazio, Carella, Massimo, Bianchini, Laurence, Perini, Giovanni, De Bellis, Gianluca, Mertens, Fredrik, Rocchi, Mariano, Storlazzi, Clelia Tiziana
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2018
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844343/
https://ncbi.nlm.nih.gov/pubmed/29279323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300552
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