Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure

Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer. Different mechanisms have been proposed to explain their genesis. Recently, our group showed that the MYC-containing dmin in leukemia cases arise by excision and amplifica...

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Detalhes bibliográficos
Main Authors: Storlazzi, Clelia Tiziana, Lonoce, Angelo, Guastadisegni, Maria C., Trombetta, Domenico, D'Addabbo, Pietro, Daniele, Giulia, L'Abbate, Alberto, Macchia, Gemma, Surace, Cecilia, Kok, Klaas, Ullmann, Reinhard, Purgato, Stefania, Palumbo, Orazio, Carella, Massimo, Ambros, Peter F., Rocchi, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928498/
https://ncbi.nlm.nih.gov/pubmed/20631050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.106252.110
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