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Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure
Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer. Different mechanisms have been proposed to explain their genesis. Recently, our group showed that the MYC-containing dmin in leukemia cases arise by excision and amplifica...
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| Autors principals: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928498/ https://ncbi.nlm.nih.gov/pubmed/20631050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.106252.110 |
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