Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure

Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer. Different mechanisms have been proposed to explain their genesis. Recently, our group showed that the MYC-containing dmin in leukemia cases arise by excision and amplifica...

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Main Authors: Storlazzi, Clelia Tiziana, Lonoce, Angelo, Guastadisegni, Maria C., Trombetta, Domenico, D'Addabbo, Pietro, Daniele, Giulia, L'Abbate, Alberto, Macchia, Gemma, Surace, Cecilia, Kok, Klaas, Ullmann, Reinhard, Purgato, Stefania, Palumbo, Orazio, Carella, Massimo, Ambros, Peter F., Rocchi, Mariano
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2010
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928498/
https://ncbi.nlm.nih.gov/pubmed/20631050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.106252.110
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