Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responses

Activated PI3K-delta syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease exhibits complex immune phenotypes including increased IgM, recurrent infection, and impaired vaccine responses. To better understand the impact of B cells in this disease, we gen...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Wray-Dutra, Michelle N., Al Qureshah, Fahd, Metzler, Genita, Oukka, Mohamed, James, Richard G., Rawlings, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170176/
https://ncbi.nlm.nih.gov/pubmed/30194267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180617
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados