Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responses

Activated PI3K-delta syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease exhibits complex immune phenotypes including increased IgM, recurrent infection, and impaired vaccine responses. To better understand the impact of B cells in this disease, we gen...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Wray-Dutra, Michelle N., Al Qureshah, Fahd, Metzler, Genita, Oukka, Mohamed, James, Richard G., Rawlings, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170176/
https://ncbi.nlm.nih.gov/pubmed/30194267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180617
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