Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth

Starting at birth, the immune system of newborns and children encounters and is influenced by environmental challenges. It is still not completely understood how γδ T cells emerge and adapt during early life. Studying the composition of T cell receptors (TCRs) using next-generation sequencing (NGS)...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Ravens, Sarina, Fichtner, Alina S., Willers, Maike, Torkornoo, Dennis, Pirr, Sabine, Schöning, Jennifer, Deseke, Malte, Sandrock, Inga, Bubke, Anja, Wilharm, Anneke, Dodoo, Daniel, Egyir, Beverly, Flanagan, Katie L., Steinbrück, Lars, Dickinson, Paul, Ghazal, Peter, Adu, Bright, Viemann, Dorothee, Prinz, Immo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414158/
https://ncbi.nlm.nih.gov/pubmed/32690687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922588117
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