Genetic models reveal origin, persistence and non-redundant functions of IL-17–producing γδ T cells

γδ T cells are highly conserved in jawed vertebrates, suggesting an essential role in the immune system. However, γδ T cell–deficient Tcrd(−/−) mice display surprisingly mild phenotypes. We hypothesized that the lack of γδ T cells in constitutive Tcrd(−/−) mice is functionally compensated by other l...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Sandrock, Inga, Reinhardt, Annika, Ravens, Sarina, Binz, Christoph, Wilharm, Anneke, Martins, Joana, Oberdörfer, Linda, Tan, Likai, Lienenklaus, Stefan, Zhang, Baojun, Naumann, Ronald, Zhuang, Yuan, Krueger, Andreas, Förster, Reinhold, Prinz, Immo
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279411/
https://ncbi.nlm.nih.gov/pubmed/30455268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181439
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