Activated PIK3CD drives innate B cell expansion yet limits B cell–intrinsic immune responses

Activated PI3K-delta syndrome (APDS) is an immunodeficiency caused by gain-of-function mutations in PIK3CD. This disease exhibits complex immune phenotypes including increased IgM, recurrent infection, and impaired vaccine responses. To better understand the impact of B cells in this disease, we gen...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Wray-Dutra, Michelle N., Al Qureshah, Fahd, Metzler, Genita, Oukka, Mohamed, James, Richard G., Rawlings, David J.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2018
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170176/
https://ncbi.nlm.nih.gov/pubmed/30194267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180617
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires