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One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation
We developed a method for rapid generation of B cell receptor (BCR) monoclonal mice expressing prerearranged Igh and Igk chains monoallelically from the Igh locus by CRISPR-Cas9 injection into fertilized oocytes. B cells from these mice undergo somatic hypermutation (SHM), class switch recombination...
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Publicado no: | J Exp Med |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Rockefeller University Press
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6170169/ https://ncbi.nlm.nih.gov/pubmed/30181412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20172064 |
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