WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from granzyme B-induced cell death. This was reversed with...

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Vydáno v:Oncoimmunology
Hlavní autoři: Sun, Lillian, Moore, Ellen, Berman, Rose, Clavijo, Paul E., Saleh, Anthony, Chen, Zhong, Van Waes, Carter, Davies, John, Friedman, Jay, Allen, Clint T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169577/
https://ncbi.nlm.nih.gov/pubmed/30288354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1488359
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