Neoadjuvant PD-1 immune checkpoint blockade reverses functional immunodominance among tumor-antigen specific T cells

PURPOSE: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus-negative head and neck squamous cell carcinoma. However, even when pathologic disease-free margins can be achieved, locoregional and/or distant d...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Friedman, Jay, Moore, Ellen C., Zolkind, Paul, Robbins, Yvette, Clavijo, Paul E., Sun, Lilian, Greene, Sarah, Morisada, Megan, Mydlarz, Wojciech, Schmitt, Nicole, Hodge, James, Schreiber, Hans, Van Waes, Carter, Uppaluri, Ravindra, Allen, Clint T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002203/
https://ncbi.nlm.nih.gov/pubmed/31645352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2209
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