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Neoadjuvant PD-1 immune checkpoint blockade reverses functional immunodominance among tumor-antigen specific T cells

PURPOSE: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus-negative head and neck squamous cell carcinoma. However, even when pathologic disease-free margins can be achieved, locoregional and/or distant d...

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Foilsithe in:Clin Cancer Res
Main Authors: Friedman, Jay, Moore, Ellen C., Zolkind, Paul, Robbins, Yvette, Clavijo, Paul E., Sun, Lilian, Greene, Sarah, Morisada, Megan, Mydlarz, Wojciech, Schmitt, Nicole, Hodge, James, Schreiber, Hans, Van Waes, Carter, Uppaluri, Ravindra, Allen, Clint T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002203/
https://ncbi.nlm.nih.gov/pubmed/31645352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2209
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