Neoadjuvant PD-1 immune checkpoint blockade reverses functional immunodominance among tumor-antigen specific T cells

PURPOSE: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus-negative head and neck squamous cell carcinoma. However, even when pathologic disease-free margins can be achieved, locoregional and/or distant d...

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Pubblicato in:Clin Cancer Res
Autori principali: Friedman, Jay, Moore, Ellen C., Zolkind, Paul, Robbins, Yvette, Clavijo, Paul E., Sun, Lilian, Greene, Sarah, Morisada, Megan, Mydlarz, Wojciech, Schmitt, Nicole, Hodge, James, Schreiber, Hans, Van Waes, Carter, Uppaluri, Ravindra, Allen, Clint T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002203/
https://ncbi.nlm.nih.gov/pubmed/31645352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2209
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