Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair and survival. Wee1 kinase inhibition reverses the ability of tumor cells to pause at G2/M. Here, we hypothesized that AZD1775, a small molecule...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Patel, Priya, Sun, Lily, Robbins, Yvette, Clavijo, Paul E., Friedman, Jay, Silvin, Christopher, Van Waes, Carter, Cook, John, Mitchell, James, Allen, Clint
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791428/
https://ncbi.nlm.nih.gov/pubmed/31646086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1638207
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