Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair and survival. Wee1 kinase inhibition reverses the ability of tumor cells to pause at G2/M. Here, we hypothesized that AZD1775, a small molecule...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Patel, Priya, Sun, Lily, Robbins, Yvette, Clavijo, Paul E., Friedman, Jay, Silvin, Christopher, Van Waes, Carter, Cook, John, Mitchell, James, Allen, Clint
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791428/
https://ncbi.nlm.nih.gov/pubmed/31646086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1638207
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados