PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR used for many tumor types including head and neck s...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Morisada, Megan, Clavijo, Paul E., Moore, Ellen, Sun, Lillian, Chamberlin, Michael, Van Waes, Carter, Hodge, James W., Mitchell, James B., Friedman, Jay, Allen, Clint T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790397/
https://ncbi.nlm.nih.gov/pubmed/29399393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1395996
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