Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

BACKGROUND: Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes. NK cells and T-lymphocytes mediate early killing of targets through a common granzyme B-dependent mechanism. Tumor cell resi...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Friedman, Jay, Morisada, Megan, Sun, Lillian, Moore, Ellen C., Padget, Michelle, Hodge, James W., Schlom, Jeffrey, Gameiro, Sofia R., Allen, Clint T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011473/
https://ncbi.nlm.nih.gov/pubmed/29925431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0374-2
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