p53 Expression in Lung Fibroblasts Is Linked to Mitigation of Fibrotic Lung Remodeling

Idiopathic pulmonary fibrosis (IPF) is a debilitating, incurable, and life-threatening disease. A cardinal feature of the pathogenesis of IPF is excessive extracellular matrix deposition attributable to proliferation of activated fibrotic lung fibroblasts (fLfs). To assess the underlying mechanism,...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Nagaraja, M.R., Tiwari, Nivedita, Shetty, Shwetha K., Marudamuthu, Amarnath S., Fan, Liang, Ostrom, Rennolds S., Fu, Jian, Gopu, Venkadesaperumal, Radhakrishnan, Vijay, Idell, Steven, Shetty, Sreerama
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168957/
https://ncbi.nlm.nih.gov/pubmed/30253845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.07.005
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