Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and Plasminogen Activator Inhibitor-1

Alveolar type II epithelial cell (ATII) apoptosis and proliferation of mesenchymal cells are the hallmarks of idiopathic pulmonary fibrosis, a devastating disease of unknown cause characterized by alveolar epithelial injury and progressive fibrosis. We used a mouse model of bleomycin (BLM)–induced l...

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Bibliographic Details
Main Authors: Bhandary, Yashodhar P., Shetty, Shwetha K., Marudamuthu, Amarnath S., Ji, Hong-Long, Neuenschwander, Pierre F., Boggaram, Vijay, Morris, Gilbert F., Fu, Jian, Idell, Steven, Shetty, Sreerama
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2013
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702744/
https://ncbi.nlm.nih.gov/pubmed/23665346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.03.022
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