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Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells

Pulmonary surfactant protein C (SP-C) expression by type II alveolar epithelial cells (AECs) is markedly reduced in diverse types of lung injuries and is often associated with AEC apoptosis. It is unclear whether loss of SP-C contributes to the increased p53 and urokinase-type plasminogen activator...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Puthusseri, Bijesh, Marudamuthu, Amarnath, Tiwari, Nivedita, Fu, Jian, Idell, Steven, Shetty, Sreerama
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495940/
https://ncbi.nlm.nih.gov/pubmed/28385810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00291.2016
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