Plasminogen Activator Inhibitor-1 Suppresses Profibrotic Responses in Fibroblasts from Fibrotic Lungs

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive interstitial scarification. A hallmark morphological lesion is the accumulation of myofibroblasts or fibrotic lung fibroblasts (FL-fibroblasts) in areas called fibroblastic foci. We previously demonstrated that...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Marudamuthu, Amarnath S., Shetty, Shwetha K., Bhandary, Yashodhar P., Karandashova, Sophia, Thompson, Michael, Sathish, Venkatachalem, Florova, Galina, Hogan, Taryn B., Pabelick, Christina M., Prakash, Y. S., Tsukasaki, Yoshikazu, Fu, Jian, Ikebe, Mitsuo, Idell, Steven, Shetty, Sreerama
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392249/
https://ncbi.nlm.nih.gov/pubmed/25648892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601815
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