Plasminogen Activator Inhibitor-1 Suppresses Profibrotic Responses in Fibroblasts from Fibrotic Lungs

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive interstitial scarification. A hallmark morphological lesion is the accumulation of myofibroblasts or fibrotic lung fibroblasts (FL-fibroblasts) in areas called fibroblastic foci. We previously demonstrated that...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Marudamuthu, Amarnath S., Shetty, Shwetha K., Bhandary, Yashodhar P., Karandashova, Sophia, Thompson, Michael, Sathish, Venkatachalem, Florova, Galina, Hogan, Taryn B., Pabelick, Christina M., Prakash, Y. S., Tsukasaki, Yoshikazu, Fu, Jian, Ikebe, Mitsuo, Idell, Steven, Shetty, Sreerama
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392249/
https://ncbi.nlm.nih.gov/pubmed/25648892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601815
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