Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators

In view of the role of sEH (soluble epoxide hydrolase) in hypertension, we have developed a rigorously validated pharmacophore model containing one HBA (Hydrogen Bond Acceptor), two HY (Hydrophobic) and one RA (Ring Aromatic) features. The model was used as a query to search the NCI (National Cancer...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Tripathi, Neetika, Paliwal, Sarvesh, Sharma, Swapnil, Verma, Kanika, Gururani, Ritika, Tiwari, Akanksha, Verma, Amrita, Chauhan, Monika, Singh, Aarti, Kumar, Dipak, Pant, Aditya
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168526/
https://ncbi.nlm.nih.gov/pubmed/30279487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32449-4
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