Computational design of chemogenetic and optogenetic split proteins

Controlling protein activity with chemogenetics and optogenetics has proven to be powerful for testing hypotheses regarding protein function in rapid biological processes. Controlling proteins by splitting them and then rescuing their activity through inducible reassembly offers great potential to c...

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Udgivet i:Nat Commun
Main Authors: Dagliyan, Onur, Krokhotin, Andrey, Ozkan-Dagliyan, Irem, Deiters, Alexander, Der, Channing J., Hahn, Klaus M., Dokholyan, Nikolay V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168510/
https://ncbi.nlm.nih.gov/pubmed/30279442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06531-4
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