Mutational processes shape the landscape of TP53 mutations in human cancer

Unlike most tumor suppressor genes, the most common genetic alterations in TP53 are missense mutations(1,2). Mutant p53 protein is often abundantly expressed in cancers, and specific allelic variants exhibit dominant-negative or gain-of-function activities in experimental models(3–8). To gain a syst...

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Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Giacomelli, Andrew O., Yang, Xiaoping, Lintner, Robert E., McFarland, James M., Duby, Marc, Kim, Jaegil, Howard, Thomas P., Takeda, David Y., Ly, Seav Huong, Kim, Eejung, Gannon, Hugh S., Hurhula, Brian, Sharpe, Ted, Goodale, Amy, Fritchman, Briana, Steelman, Scott, Vazquez, Francisca, Tsherniak, Aviad, Aguirre, Andrew J., Doench, John G., Piccioni, Federica, Roberts, Charles W. M., Meyerson, Matthew, Getz, Gad, Johannessen, Cory M., Root, David E., Hahn, William C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168352/
https://ncbi.nlm.nih.gov/pubmed/30224644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0204-y
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