Mutational processes shape the landscape of TP53 mutations in human cancer

Unlike most tumor suppressor genes, the most common genetic alterations in TP53 are missense mutations(1,2). Mutant p53 protein is often abundantly expressed in cancers, and specific allelic variants exhibit dominant-negative or gain-of-function activities in experimental models(3–8). To gain a syst...

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Udgivet i:Nat Genet
Main Authors: Giacomelli, Andrew O., Yang, Xiaoping, Lintner, Robert E., McFarland, James M., Duby, Marc, Kim, Jaegil, Howard, Thomas P., Takeda, David Y., Ly, Seav Huong, Kim, Eejung, Gannon, Hugh S., Hurhula, Brian, Sharpe, Ted, Goodale, Amy, Fritchman, Briana, Steelman, Scott, Vazquez, Francisca, Tsherniak, Aviad, Aguirre, Andrew J., Doench, John G., Piccioni, Federica, Roberts, Charles W. M., Meyerson, Matthew, Getz, Gad, Johannessen, Cory M., Root, David E., Hahn, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168352/
https://ncbi.nlm.nih.gov/pubmed/30224644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0204-y
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