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How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma

Rap proteins regulate liver physiopathology. For example, Rap2B promotes hepatocarcinoma (HCC) growth, while Rap1 might play a dual role. The RapGEF, Epac1, activates Rap upon cAMP binding, regulating metabolism, survival, and liver regeneration. A liver specific Epac2 isoform lacking cAMP-binding d...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hepat Oncol
Prif Awduron: Sequera, Celia, Manzano, Sara, Guerrero, Carmen, Porras, Almudena
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Future Medicine Ltd 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168044/
https://ncbi.nlm.nih.gov/pubmed/30302196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/hep-2017-0026
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