C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms

C3G, a Guanine nucleotide Exchange Factor (GEF) for Rap1 and R-Ras, has been shown to play important roles in development and cancer. Previous studies determined that C3G regulates cell death through down-regulation of p38α MAPK activity. Here, we found that C3G knock-down in MEFs and HCT116 cells p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Priego, Neibla, Arechederra, María, Sequera, Celia, Bragado, Paloma, Vázquez-Carballo, Ana, Gutiérrez-Uzquiza, Álvaro, Martín-Granado, Víctor, Ventura, Juan José, Kazanietz, Marcelo G., Guerrero, Carmen, Porras, Almudena
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216706/
https://ncbi.nlm.nih.gov/pubmed/27286263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9911
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