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How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma
Rap proteins regulate liver physiopathology. For example, Rap2B promotes hepatocarcinoma (HCC) growth, while Rap1 might play a dual role. The RapGEF, Epac1, activates Rap upon cAMP binding, regulating metabolism, survival, and liver regeneration. A liver specific Epac2 isoform lacking cAMP-binding d...
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| Publicado no: | Hepat Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Future Medicine Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168044/ https://ncbi.nlm.nih.gov/pubmed/30302196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/hep-2017-0026 |
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