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Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration
BACKGROUND: Mammalian target of rapamycin (mTOR) is a master regulator of various cellular responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is frequently dysregulated in pancreatic neuroendocrine tumors (PNETs). mTOR inhibitors have been used in attempts to treat thes...
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| Pubblicato in: | Cell Commun Signal |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6167842/ https://ncbi.nlm.nih.gov/pubmed/30285764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-018-0278-2 |
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