(18)F-XTRA PET for Enhanced Imaging of the Extrathalamic α4β2 Nicotinic Acetylcholine Receptor

Reduced density of the α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) in the cortex and hippocampus of the human brain has been reported in aging and patients with neurodegenerative disease. This study assessed the pharmacokinetic behavior of (18)F-(−)-JHU86428 ((18)F-XTRA), a new radiotracer fo...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Coughlin, Jennifer M., Slania, Stephanie, Du, Yong, Rosenthal, Hailey B., Lesniak, Wojciech G., Minn, Il, Smith, Gwenn S., Dannals, Robert F., Kuwabara, Hiroto, Wong, Dean F., Wang, Yuchuan, Horti, Andrew G., Pomper, Martin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2018
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167533/
https://ncbi.nlm.nih.gov/pubmed/29496987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205492
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