Učitavanje...
Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain
KEY POINTS: In the human ether‐a‐go‐go related gene (hERG) channel, both the ether‐a‐go‐go (EAG) domain in the N‐terminal and the cyclic nucleotide (CN) binding homology (CNBH) domain in the C‐terminal cytoplasmic region are known to contribute to the characteristic slow deactivation. Mutations of P...
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| Izdano u: | J Physiol |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166088/ https://ncbi.nlm.nih.gov/pubmed/30086184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276208 |
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