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Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels
Human ether-á-go-go (eag)-related gene (hERG) potassium channels play a critical role in cardiac repolarization and are characterized by unusually slow closing (deactivation) kinetics. The N-terminal “eag” domain and a C-terminal C-linker/cyclic nucleotide–binding homology domain (CNBHD) are require...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787778/ https://ncbi.nlm.nih.gov/pubmed/24043860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310995 |
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