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The eag domain regulates hERG channel inactivation gating via a direct interaction

Human ether-á-go-go (eag)-related gene (hERG) potassium channel kinetics are characterized by rapid inactivation upon depolarization, along with rapid recovery from inactivation and very slow closing (deactivation) upon repolarization. These factors combine to create a resurgent hERG current, where...

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Detalhes bibliográficos
Main Authors: Gustina, Ahleah S., Trudeau, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557309/
https://ncbi.nlm.nih.gov/pubmed/23319729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210870
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