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hERG potassium channel gating is mediated by N- and C-terminal region interactions
Human ether-á-go-go–related gene (hERG) potassium channels have voltage-dependent closing (deactivation) kinetics that are unusually slow. A Per-Arnt-Sim (PAS) domain in the cytoplasmic N-terminal region of hERG regulates slow deactivation by making a direct interaction with another part of the hERG...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047612/ https://ncbi.nlm.nih.gov/pubmed/21357734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010582 |
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