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A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

Human ether á go-go related gene (hERG) potassium channels play a central role in cardiac repolarization where channel closing (deactivation) regulates current density during action potentials. Consequently, mutations in hERG that perturb deactivation are linked to long QT syndrome (LQTS), a catastr...

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Autori principali: Gustina, Ahleah S., Trudeau, Matthew C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722319/
https://ncbi.nlm.nih.gov/pubmed/19651618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900180106
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