Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K(+) Channel Deactivation Gating from the Solution Structure of the EAG Domain

Human ether-à-go-go-related gene (hERG) K(+) channels have a critical role in cardiac repolarization. hERG channels close (deactivate) very slowly, and this is vital for regulating the time course and amplitude of repolarizing current during the cardiac action potential. Accelerated deactivation is...

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Autores principales: Muskett, Frederick W., Thouta, Samrat, Thomson, Steven J., Bowen, Alexander, Stansfeld, Phillip J., Mitcheson, John S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057830/
https://ncbi.nlm.nih.gov/pubmed/21135103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199364
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