Very Low Numbers of CD4(+)FoxP3(+) Tregs Expanded in Donors via TL1A-Ig and Low Dose IL-2 Exhibit a Distinct Activation / Functional Profile and Suppress GVHD in a Pre-clinical Model

Regulatory T cells (Tregs) are essential for the maintenance of tolerance and immune homeostasis. In allogeneic hematopoietic stem cell transplantation (aHSCT), transfer of appropriate Treg numbers is a promising therapy for the prevention of graft-versus-host disease (GVHD). We have recently report...

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Bibliographic Details
Published in:Biol Blood Marrow Transplant
Main Authors: Copsel, Sabrina, Wolf, Dietlinde, Kale, Brandon, Barreras, Henry, Lightbourn, Casey O., Bader, Cameron S., Alperstein, W., Altman, Norman H., Komanduri, Krishna V., Levy, Robert B.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6163068/
https://ncbi.nlm.nih.gov/pubmed/29751114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2018.04.026
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