Marked in vivo Donor Treg Expansion via IL-2 and TL1A-Ig stimulation ameliorates GVHD but preserves GVL in recipients post-HSCT

Regulatory T cells (Tregs) are critical for self-tolerance. While adoptive transfer of expanded Tregs limits graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), ex vivo generation of large numbers of functional Tregs remains difficult. Here, we demonstrate that in vivo t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biol Blood Marrow Transplant
Main Authors: Wolf, Dietlinde, Barreras, Henry, Bader, Cameron S., Copsel, Sabrina, Lightbourn, Casey O., Pfeiffer, Brent J., Altman, Norman H., Podack, Eckhard R., Komanduri, Krishna V., Levy, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625339/
https://ncbi.nlm.nih.gov/pubmed/28219835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2017.02.013
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados