Marked in vivo Donor Treg Expansion via IL-2 and TL1A-Ig stimulation ameliorates GVHD but preserves GVL in recipients post-HSCT

Regulatory T cells (Tregs) are critical for self-tolerance. While adoptive transfer of expanded Tregs limits graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT), ex vivo generation of large numbers of functional Tregs remains difficult. Here, we demonstrate that in vivo t...

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Veröffentlicht in:Biol Blood Marrow Transplant
Hauptverfasser: Wolf, Dietlinde, Barreras, Henry, Bader, Cameron S., Copsel, Sabrina, Lightbourn, Casey O., Pfeiffer, Brent J., Altman, Norman H., Podack, Eckhard R., Komanduri, Krishna V., Levy, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625339/
https://ncbi.nlm.nih.gov/pubmed/28219835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2017.02.013
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