Superior immune reconstitution using Treg-expanded donor cells versus PTCy treatment in preclinical HSCT models

Posttransplant cyclophosphamide (PTCy) has been found to be effective in ameliorating acute graft-versus-host disease (GVHD) in patients following allogeneic hematopoietic stem cell transplantation (aHSCT). Adoptive transfer of high numbers of donor Tregs in experimental aHSCT has shown promise as a...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Wolf, Dietlinde, Bader, Cameron S., Barreras, Henry, Copsel, Sabrina, Pfeiffer, Brent J., Lightbourn, Casey O., Altman, Norman H., Komanduri, Krishna V., Levy, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237457/
https://ncbi.nlm.nih.gov/pubmed/30333311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121717
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