STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

The STING pathway has been proposed as a key regulator of gastrointestinal homeostasis and inflammatory responses. Although STING reportedly protects against gut barrier damage and graft-versus-host disease (GVHD) after MHC-mismatched aHSCT, its effect in clinically relevant MHC-matched allogeneic h...

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Udgivet i:Sci Transl Med
Main Authors: Bader, Cameron S, Barreras, Henry, Lightbourn, Casey O, Copsel, Sabrina N, Wolf, Dietlinde, Meng, Jingjing, Ahn, Jeonghyun, Komanduri, Krishna V, Blazar, Bruce R, Jin, Lei, Barber, Glen N, Roy, Sabita, Levy, Robert B
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7392054/
https://ncbi.nlm.nih.gov/pubmed/32669421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aay5006
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