Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

BACKGROUND: Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO(2) to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS: We used (1...

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書誌詳細
出版年:Br J Cancer
主要な著者: Lee, Shen-Han, McIntyre, Dominick, Honess, Davina, Hulikova, Alzbeta, Pacheco-Torres, Jesús, Cerdán, Sebastián, Swietach, Pawel, Harris, Adrian L., Griffiths, John R.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162214/
https://ncbi.nlm.nih.gov/pubmed/30206370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0216-5
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