Intracellular Carbonic Anhydrase Activity Sensitizes Cancer Cell pH Signaling to Dynamic Changes in CO(2) Partial Pressure

Carbonic anhydrase (CA) enzymes catalyze the chemical equilibration among CO(2), HCO(3)(−) and H(+). Intracellular CA (CA(i)) isoforms are present in certain types of cancer, and growing evidence suggests that low levels correlate with disease severity. However, their physiological role remains uncl...

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Autores principales: Hulikova, Alzbeta, Aveyard, Nicholas, Harris, Adrian L., Vaughan-Jones, Richard D., Swietach, Pawel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162147/
https://ncbi.nlm.nih.gov/pubmed/25059669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547844
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