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The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

We have studied the role of carbonic anhydrase 9 (CA9), a cancer-associated extracellular isoform of the enzyme carbonic anhydrase in multicellular spheroid growths (radius of ∼300 μm) of human colon carcinoma HCT116 cells. Spheroids were transfected with CA9 (or empty vector) and imaged confocally...

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Bibliografiska uppgifter
Huvudupphovsmän: Swietach, Pawel, Patiar, Shalini, Supuran, Claudiu T., Harris, Adrian L., Vaughan-Jones, Richard D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740455/
https://ncbi.nlm.nih.gov/pubmed/19458084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006478
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