Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

BACKGROUND: Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO(2) to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS: We used (1...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Lee, Shen-Han, McIntyre, Dominick, Honess, Davina, Hulikova, Alzbeta, Pacheco-Torres, Jesús, Cerdán, Sebastián, Swietach, Pawel, Harris, Adrian L., Griffiths, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162214/
https://ncbi.nlm.nih.gov/pubmed/30206370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0216-5
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