Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

BACKGROUND: Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO(2) to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS: We used (1...

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Publicat a:Br J Cancer
Autors principals: Lee, Shen-Han, McIntyre, Dominick, Honess, Davina, Hulikova, Alzbeta, Pacheco-Torres, Jesús, Cerdán, Sebastián, Swietach, Pawel, Harris, Adrian L., Griffiths, John R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162214/
https://ncbi.nlm.nih.gov/pubmed/30206370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0216-5
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