Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana

Sulfadoxine-pyrimethamine (SP) is used as malaria chemoprophylaxis for pregnant women and children in Ghana. Plasmodium falciparum resistance to SP is linked to mutations in the dihydropteroate synthase gene (pfdhps), dihydrofolate reductase gene (pfdhfr) and amplification of GTP cyclohydrolase 1 (p...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Osei, Musah, Ansah, Felix, Matrevi, Sena A., Asante, Kwaku P., Awandare, Gordon A., Quashie, Neils B., Duah, Nancy O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162080/
https://ncbi.nlm.nih.gov/pubmed/30265714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204871
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