Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana

Sulfadoxine-pyrimethamine (SP) is used as malaria chemoprophylaxis for pregnant women and children in Ghana. Plasmodium falciparum resistance to SP is linked to mutations in the dihydropteroate synthase gene (pfdhps), dihydrofolate reductase gene (pfdhfr) and amplification of GTP cyclohydrolase 1 (p...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Osei, Musah, Ansah, Felix, Matrevi, Sena A., Asante, Kwaku P., Awandare, Gordon A., Quashie, Neils B., Duah, Nancy O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162080/
https://ncbi.nlm.nih.gov/pubmed/30265714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204871
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